Please note that pdf files downloaded from this site are for personal use only and may not be made available elsewhere or distributed.
92.E. Ambrose-Dempster, L. Leipold, D. Dobrijevic, M. Bawn, E. M. Carter, G. Stojanovski, T. D. Sheppard, J. W. E. Jeffries, J. M. Ward, H. C. Hailes, Mechanoenzymatic reactions for the hydrolysis of PET, RSC Advances, 2023, 13, 9954. doi: 10.1039/d3ra01708g
91. Y. Wang, F. Subrizi, E. M. Carter, T. D. Sheppard, J. M. Ward, H. C. Hailes, Enzymatic synthesis of benzylisoquinoline alkaloids using a parallel cascade strategy and tyrosinase variants, Nature Communications, 2022, 13, 5436. doi: 10.1038/s41467-022-33122-1 Direct Link
90. A. S. Dumon, H. S. Rzepa, C. Alamillo-Ferrer, J. Bures, R. Procter, T. D. Sheppard, A. Whiting, A computational tool to accurately and quickly predict 19F NMR chemical shifts of molecules with fluorine-carbon and fluorine-boron bonds, Physical Chemistry & Chemical Physics, 2022, 24, 20409. doi: 10.1039/D2CP02317B Preprint
89. S. St John Campbell, T. D. Sheppard, Imine Azaenolates: Synthesis, Reactivity and Outlook, Advanced Synthesis & Catalysis, 2022, 364, 2674. doi: 10.1002/adsc.202200262
88. N. Ahmed, R. J. Spears, T. D. Sheppard, V. Chudasama, Functionalisation of ethereal-based saturated heterocycles with concomitant aerobic C–H activation and C–C bond formation, Chemical Science 2022, 13, 8626. doi: 10.1039/D2SC01626E
87. J. Singh, D. Whitaker, B. Thoma, S. Islam, C. S. Foden, A. E. Aliev, T. D. Sheppard, M. W. Powner, Prebiotic Catalytic Peptide Ligation Yields Proteinogenic Peptides by Intramolecular Amide Catalyzed Hydrolysis Facilitating Regioselective Lysine Ligation in Neutral Water, Journal of the American Chemical Society 2022, 144, 10151. doi: 10.1021/jacs.2c03486
86. E. M. Carter, E. Ambrose-Dempster, J. M. Ward, T. D. Sheppard, H. C. Hailes, Mechanoenzymatic reactions with whole cell transaminases: shaken, not stirred, Green Chemistry 2022, 24, 3662. doi: 10.1039/D2GC01006B
85. T. Nishikata, T. D. Sheppard, N. Tsuchiya, Tertiary Alkylative Suzuki-Miyaura Couplings, Synthesis 2022, 2340. doi: 10.1055/a-1732-4597
84. E. Carter, F. Subrizi, J. M. Ward, T. D. Sheppard, H. C. Hailes, Direct Comversion of Hydrazones to Amines using Transaminases, ChemCatChem 2021, 13, 4520. Open Access doi: 10.1002/cctc.202101008
83. R. Szpara, A. Goyder, M. J. Porter, H. C. Hailes, T. D. Sheppard, Regioselective Dehydration of Sugar Thioacetals under Mild Conditions, Organic Letters 2021, 23, 2488. Open Access doi: 10.1021/acs.orglett.1c00424 Preprint
82. C. S. Foden, S. Islam, C. A. Fernandez Garcia, L. Maugeri, T. D. Sheppard, M. W. Powner, Prebiotic Synthesis of Cysteine Peptides That Catalyze Peptide Ligation in Neutral Water, Science 2020, 370, 865. UCL RPS link doi: 10.1126/science.abd5680. Preprint
81. C. E. Coomber, M. J. Porter, A. E. Aliev, P. D. Smith, T. D. Sheppard, Tuning Reactivity in Pd-Catalysed C(sp3)-H Arylations via Directing Group Modifications and Solvent Selection, Advanced Synthesis & Catalysis 2020, 362, 5105. Open Access doi: 10.1002/adsc.202000726 DFT xyz files Preprint
80. Y. Nakashima, G. Hirata, T. D. Sheppard, T. Nishikata, The Mizoroki-Heck reaction with internal okefins: Reactivities and stereoselectivities, Asian Journal of Organic Chemistry 2020, 9, 480. doi: 10.1002/ajoc.201900741
79. H. Yu, R. I. Hernández López D. Steadman, D. Méndez‐Sánchez, S. Higson, A. Cázares‐Körner, T. D. Sheppard, J. M. Ward, H. C. Hailes, P. A. Dalby, Engineering transketolase to accept both unnatural donor and acceptor substrates and produce α‐hydroxyketones, The FEBS Journal 2019, 287, 1758. doi: 10.1111/febs.15108
78. K. Takeuchi, Y. Murata, G. Hirata, T. D. Sheppard, T. Nishikata, Hybrid Reaction Systems for the Synthesis of Alkylated Compounds based upon Cu‐catalyzed Coupling of Radicals and Organometallic Species, The Chemical Record 2019, 20, 403. doi: 10.1002/tcr.201900053
77. V. Laserna, M. J. Porter, T. D. Sheppard, Gold Catalyzed Hydroamination of Propargylic Alcohols: Controlling Divergent Reaction Pathways to Access 1,3-Aminoalcohols, 3-Hydroxyketones or 3-Aminoketones, The Journal of Organic Chemistry, 2019, 84, 11391. doi: 10.1021/acs.joc.9b00988 Preprint
76. C. E. Coomber, V. Laserna, L. T. Martin, P. D. Smith, H. C. Hailes, M. J. Porter, T. D. Sheppard, Catalytic Direct Amidations in tert-Butyl Acetate Using B(OCH2CF3)3, Organic & Biomolecular Chemistry, 2019, 17, 6465. Open Access doi: 10.1039/C9OB01012B Preprint
75. V. Laserna, C. Jeapes Rojas, T. D. Sheppard, Gold-Catalyzed Hydrophenoxylation of Propargylic Alcohols and Amines: Synthesis of Phenyl Enol Ethers, Organic Letters 2019, 21, 4443. doi: 10.1021/acs.orglett.9b01208
74. L. Benhamou, R. W. Foster, D. P. Ward, K. Wheelhouse, L. Sloan, C. J. Tame, D.-K. Bucar, G. J. Lye, H. C. Hailes, T. D. Sheppard, Functionalised tetrahydrofuran fragments from carbohydrates or sugar beet pulp biomass, Green Chemistry 2019, 21, 2035. Open Access doi: 10.1039/C9GC00448C
73. F. Subrizi, L. Benhamou, J. M. Ward, T. D. Sheppard, H. C. Hailes, Aminopolyols from carbohydrates: the amination of sugars and sugar‐derived tetrahydrofurans with transaminases, Angewandte Chemie International Edition 2019, 58, 3854. Open Access doi: 10.1002/anie.201813712
72. M. T. Sabatini, L. T. Boulton, H. F. Sneddon, T. D. Sheppard, A green chemistry perspective on catalytic amide bond formation, Nature Catalysis 2019, 2, 10. doi: 10.1038/s41929-018-0211-5 Full text
71. C. L. C. Smelt, V. R. Sanders, J. Newcombe, R. P. Burt, T. D. Sheppard, M. Topf, N. S. Millar, Identification by virtual screening and functional characterisation of novel positive and negative allosteric modulators of the α7 nicotinic acetylcholine receptor, Neuropharmacology 2018, 139, 194. doi: 10.1016/j.neuropharm.2018.07.009
70. V. Karaluka, K. Murata, S. Masuda, Y. Shiramatsu, T. Kawamoto, H. C. Hailes, T. D. Sheppard, A. Kamimura, Development of a microwave-assisted sustainable conversion of furfural hydrazones to functionalised phthalimides in ionic liquids, RSC Advances 2018, 8, 22617. Open Access doi: 10.1039/C8RA03895C
69. H. R. Rzepa, S. Arkhipenko, E. Wan, M. T. Sabatini, V. Karaluka, A. Whiting, T. D. Sheppard, An Accessible Method for DFT Calculation of 11B NMR Shifts of Organoboron Compounds, The Journal of Organic Chemistry 2018, 83, 8020. doi: 10.1021/acs.joc.8b00859
68. M. Bawn, F. Subrizi, G. J. Lye, T. D. Sheppard, H. C. Hailes, J. M. Ward, One-pot, two-step transaminase and transketolase synthesis of L-gluco-heptulose from L-arabinose, Enzyme and Microbial Technology 2018, 116, 16. Open Access. doi: 10.1016/j.enzmictec.2018.05.006
67. S. M. Gibson, J. M. D'Oyley, J. I. Higham, K. Sanders, V. Laserna, A. E. Aliev, T. D. Sheppard, Dihalohydration of Alkynols: A Versatile Approach to Diverse Halogenated Molecules, European Journal of Organic Chemistry 2018, 4018. Open Access. doi: 10.1002/ejoc.201800668
66. M. T. Sabatini, V. Karaluka, R. M. Lanigan, L. T. Boulton, M. Badland, T. D. Sheppard, Protecting group free amidation of amino acids using Lewis acid catalysts, Chemistry - A European Journal 2018, 24, 7033. Open Access. doi: 10.1002/chem.201800372
This work was higlighted in Synfacts
65. S. Ishida, T. D. Sheppard, T. Nishikata, Site selectivities in fluorination, Tetrahedron Letters 2018, 59, 789. doi: 10.1016/j.tetlet.2018.01.044
64. S. Arkhipenko, M. Sabatini, A. Batsanov, V. Karaluka, T. D. Sheppard, H. Rzepa. A. Whiting, Mechanistic insights into boron-catalysed direct amidation reactions, Chemical Science 2018, 9, 1058. Open Access. doi: 10.1039/C7SC03595K
Highlighted by Prof Andrei Yudin in his editor's choice article collection of important recent papers in the journal.
63. C. E. Coomber, L. Benhamou, D. -K. Bucar, P. D. Smith, M. J. Porter, T. D. Sheppard, Silver-Free Palladium-Catalyzed C(sp3)–H Arylation of Saturated Bicyclic Amine Scaffolds, Journal of Organic Chemistry 2018, 83, 2495. Open Access. doi: 10.1021/acs.joc.7b02665
This article was featured on the journal cover, with a design by Tom, Charlotte and Mike upon a background photo of the 'Alpspitze' in the Bavarian alps taken by Tom.
62. J. Newcombe, A. Chatzidacki, T. D. Sheppard, M. Topf, N. S. Millar, Diversity of nicotinic acetylcholine receptor positive allosteric modulators revealed by mutagenesis and a revised structural model, Molecular Pharmacology 2018, 93, 128. Open Access. doi: 10.1124/mol.117.110551
This article was featured on the journal cover.
61. S. M. Gibson, D. Macmillan, T. D. Sheppard, Synthesis of boronocysteine, Synlett 2018, 314. UCL RPS link pdf
doi: 10.1055/s-0036-1591491
60. M. T. Sabatini, L. T. Boulton, T. D. Sheppard, Borate esters: Simple catalysts for the sustainable synthesis of complex amides, Science Advances 2017, 3, e1701028. doi: 10.1126/sciadv.1701028 Open Access
This work was higlighted in Synform and highlighted in Some items of interest to Process R&D Chemists and Engineers in OPR&D.
59. S. I. Jacob, B. Khogeer, N. Bampos, T. D. Sheppard, R. M. Schwartz, C. R. Lowe, The development and application of synthetic affinity ligands for the purification of ferritin-based influenza antigens , Bioconjugate Chemistry 2017, 28, 1931. UCL RPS link doi: 10.1021/acs.bioconjchem.7b00253
58. A. Dunbabin, F. Subrizi, J. M. Ward, T. D. Sheppard, H. C. Hailes, Furfurylamines from biomass: transaminase catalysed upgrading of furfurals, Green Chemistry 2017, 19, 397. doi: 10.1039/C6GC02241C pdf Open Access
This article was featured in the inside back cover of Green Chemistry with a design by Alice and Fabiana incorporating a photo taken by Alice's dad.
57. M. Cardenas-Fernandez, M. Bawn, C. Bennett, B. Penumathsa, F. Subrizi, N. Suhaili, D. Ward, S. Bourdin, P. A Dalby, H. C. Hailes, P. Hewitson, S. Ignatova, C. Kontoravdi, D. J. Leak, N. Shah, T. D. Sheppard, J. M Ward and G. J Lye, An Integrated Biorefinery Concept for Conversion of Sugar Beet Pulp into Value-added Chemicals and Pharmaceuticals, Faraday Discussions, 2017, 202, 415. doi: 10.1039/C7FD00094D.
56. L. Benhamou, D. W. Walker, D. -K. Bucar, A. E. Aliev, T. D. Sheppard, Synthesis of substituted benzooxaborinin-1-ols via palladium- catalysed cyclisation of alkenyl- and alkynyl-boronic acids, Organic & Biomolecular Chemistry 2016, 14, 8039. doi: 10.1039/C6OB01419D. pdf
55. R. M. Lanigan, V. Karaluka, M. Sabatini, P. Starkov, M. Badland, L. Boulton, T. D. Sheppard, Direct Amidation of Unprotected Amino Acids using B(OCH2CF3)3, Chemical Communications 2016, 52, 8846. doi: 10.1039/C6CC05147B. pdf Open Access
This article was highlighted in Synfacts and in an ACS Cutting Edge Chemistry article.
54. M. N. Pennell, M. P. Kyle, S. M. Gibson, L. Male, P. G. Turner, R. S. Grainger, T. D. Sheppard, Intercepting the Gold-Catalysed Meyer–Schuster Rearrangement by Controlled Protodemetallation: A Regioselective Hydration of Propargylic Alcohols, Advanced Synthesis & Catalysis 2016, 358, 1519. doi: 10.1002/adsc.201600101. Open Access
53. F. Subrizi, M. Cardenas-Fernandez, G. J. Lye, J. M. Ward, P. A. Dalby, T. D. Sheppard, H. C. Hailes, Transketolase catalysed upgrading of L-arabinose: the one-step stereoselective synthesis of L-gluco-heptulose, Green Chemistry 2016 18, 3158. doi: 10.1039/C5GC02660A. pdf Open Access
52. S. Higson, F. Subrizi, T. D. Sheppard, H. C. Hailes, Chemical Cascades in Water for the Synthesis of Functionalized Aromatics from Furfurals, Green Chemistry 2016 18, 1855. doi: 10.1039/C5GC02935J. pdf Open Access
This article was featured in the inside back cover of Green Chemistry with a design by Sally and Fabiana incorporating a photo taken by Tom of the Tvindefossen waterfall in Norway.
51. P. M. Murray, F. Bellany, L. Benhamou, D. -K, Bucar, A. B. Tabor, T. D. Sheppard, The application of design of experiments (DoE) reaction optimisation and solvent selection in the development of new synthetic chemistry, Organic & Biomolecular Chemistry 2016 14, 2373. doi: 10.1039/C5OB01892G. pdf Open Access
This article was featured on the front cover of OBC with a design incorporating a photo taken by Tom of the ridge running between Herzogstand and Heimgarten on the edge of the Bavarian alps.
50. E. Barreiro, A. Sanz-Vidal, E. Tan, S. -H. Lau, T. D. Sheppard, S. Díez-González, HBF4-Catalysed Nucleophilic Substitutions of Propargylic Alcohols, European Journal of Organic Chemistry 2015, 34, 7544. doi: 10.1002/ejoc.201501249. Open Access
49. F. Rota, L. Benhamou, T. D. Sheppard, Asymmetric Synthesis of Secondary Alcohols and 1,2-Disubstituted Epoxides via Organocatalytic Sulfenylation, Synlett (Special Issue Celebrating the 70th Birthday of Professor Steven Ley CBE FRS) 2016, 33. doi: 10.1055/s-0035-1560769. pdf
48. R. W. Foster, C. J. Tame, D -K. Bucar, H. C. Hailes, T. D. Sheppard, The Sustainable Synthesis of Chiral Tetrahydrofurans via the Selective Dehydration of Pentoses, Chemistry - A European Journal 2015, 21, 15947. doi: 10.1002/chem.201503510. Open Access
47. S. E. Mann, L. Benhamou, T. D. Sheppard, Palladium(II)-Catalysed Oxidation of Alkenes, Synthesis, 2015, 47, 3079. doi: 10.1055/s-0035-1560465. pdf
46. V. Karaluka, R. M. Lanigan, P. M. Murray, M. Badland, T. D. Sheppard, B(OCH2CF3)3-mediated direct amidation of pharmaceutically relevant building blocks in cyclopentyl methyl ether, Organic & Biomolecular Chemistry 2015, 13, 10888. doi: 10.1039/c5ob01801c. pdf Open Access
45. S. M. Gibson, R. M. Lanigan, L. Benamou, A. E. Aliev, T. D. Sheppard, A Lactate-Derived Chiral Aldehyde for Determining the Enantiopurity of Enantioenriched Primary Amines, Organic & Biomolecular Chemistry 2015, 13, 9050. doi: 10.1039/c5ob01398d. pdf Open Access
44. A. Chatzidaki, J. M. D'Oyley, J. K. Gill-Thind, T. D. Sheppard, N. S. Millar, The influence of allosteric modulators and transmembrane mutations on desensitisation and activation of α7 nicotinic acetylcholine receptors, Neuropharmacology 2015 97, 75. doi: 10.1016/j.neuropharm.2015.05.006. Open Access
43. R. W. Foster, L. Benhamou, M. J. Porter, D. -K. Bucar, H. C. Hailes, C. J. Tame, T. D. Sheppard, Irreversible endo-Selective Diels-Alder Reactions of Substituted Alkoxyfurans: a General Synthesis of endo-Cantharimides, Chemistry - A European Journal 2015 21, 6107. doi: 10.1002/chem.201406286. Open Access
42. J. K. Gill-Thind, P. Dhankher, J. M. D'Oyley, T. D. Sheppard, N. S. Millar, Structurally similar allosteric modulators of α7 nicotinic acetylcholine receptors exhibit five distinct pharmacological effects, Journal of Biological Chemistry 2015, 290, 3552. doi: 10.1074/jbc.M114.619221.
41. T. D. Sheppard, Tris(2,2,2-trifluoroethoxy)boron, e-EROS Encyclopedia of Reagents for Organic Synthesis, 2014. doi: 10.1002/047084289X.rn01754.
40. S. A. Samchez-Vasquez, T. D. Sheppard, J. R. G Evans, H. C. Hailes, The selective conversion of D-limonene to p,α-dimethylstyrene, RSC Advances 2014 4, 61652. doi: 10.1039/c4ra11558a.
39. R. M. Lanigan, T. D. Sheppard, Recent Developments in Amide Synthesis: Direct Amidation of Carboxylic Acids and Transamidation Reactions, European Journal of Organic Chemistry 2013, 7453. doi: 10.1002/ejoc.201300573. UCL RPS link
38. P. Dhankher, L. Benhamou, T. D. Sheppard, Rapid Assembly of Functionalised Spirocyclic Indolines by Palladium-Catalysed Dearomatising Diallylation of Indoles with Allyl Acetate, Chemistry - A European Journal 2014 20, 13375. doi: 10.1002/chem.201403940. UCL RPS link Open Access
37. J. M. D'Oyley, A. E. Aliev, T. D. Sheppard, Regioselective Dihalohydration Reactions of Propargylic Alcohols: Gold-Catalyzed and Non-Catalyzed Reactions, Angewandte Chemie International Edition 2014 53, 10747. doi: 10.1002/anie.201405348. UCL RPS link Open Access
36. M. N. Pennell, R. W. Foster, P. G. Turner, H. C. Hailes, C. J. Tame, T. D. Sheppard, Gold catalysed synthesis of 3-alkoxyfurans at room temperature, Chemical Communications 2014 50, 1302. doi: 10.1055/s-0033-1340302. UCL RPS link Open Access
35. P. Dhankher, T. D. Sheppard, A Convenient Synthesis of Tri- and Tetramethylbenzaldehydes from Readily Available Phenols, Synlett 2014, 381. doi: 10.1055/s-0033-1340302. UCL RPS linkpdf
34. R. W. Foster, C. J. Tame, H. C. Hailes, T. D. Sheppard, Highly Regioselective Synthesis of Substituted Isoindolinones via Ruthenium-Catalyzed Alkyne Cyclotrimerizations, Advanced Synthesis & Catalysis 2013, 355, 2353. doi: 10.1002/adsc.201300055. UCL RPS link Open Access
33. A. E. Aliev, M. Kulke, H. S. Khaneja, V. Chudasama, T. D. Sheppard, R. M. Lanigan, Motional timescale predictions by molecular dynamics simulations: Case study using proline and hydroxyproline sidechain dynamics, Proteins 2014, 82, 195. doi: 10.1002/prot.24350 UCL RPS link Open Access.
32. R. M. Lanigan, P. Starkov and T. D. Sheppard, Direct Synthesis of Amides from Carboxylic Acids and Amines Using B(OCH2CF3)3, The Journal of Organic Chemistry 2013, 78, 4512. doi:10.1021/jo400509n. UCL RPS link Open Access
Highlighted on www.organic-chemistry.org.
This article regularly appears in the most read articles (past 12 months) in JOC.
31. T. D. Sheppard and T. N. Snaddon, Highlights from the 47th EUCHEM Conference on Stereochemistry, Bürgenstock, Switzerland, May 2012, Chemical Communications 2012, 48, 11597. doi:10.1039/C2CC90366K pdf. UCL RPS link
30. P. Starkov, F. Rota, J. M. D'Oyley and T. D. Sheppard, Catalytic Electrophilic Halogenation of Silyl-Protected and Terminal Alkynes: Trapping Gold(I) Acetylides vs. a Brønsted Acid-Promoted Reaction, Advanced Synthesis & Catalysis 2012, 354, 3217. doi:10.1002/adsc.201200491. UCL RPS link
29. T. D. Sheppard, Complexity-generating hydration reactions via gold-catalyzed addition of boronic acids to alkynes, Pure and Applied Chemistry 2012, 84, 2431. doi:10.1351/PAC-CON-12-01-08. UCL RPS link
28. M. N. Pennell, P. G. Turner and T. D. Sheppard, Gold and Silver Catalyzed Reactions of Propargylic Alcohols in the Presence of Protic Additives, Chemistry - A European Journal 2012, 18, 4748. doi:10.1002/chem.201102830. UCL RPS link
27. J. K. Gill, P. Dhankher, T. D. Sheppard, E. Sher, N. S Millar, A Series of α7 Nicotinic Acetylcholine Receptor Allosteric Modulators with Close Chemical Similarity but Diverse Pharmacological Properties, Molecular Pharmacology, 2012, 81, 710. doi:10.1124/mol.111.076026 UCL RPS link Open Access
26. M. Bachman, S. E. Mann, T. D. Sheppard, Rapid Synthesis of Highly Functionalised Alpha-Amino Amides and Medium Ring Lactones using Multicomponent Reactions of Amino Alcohols and Isocyanides , Organic and Biomolecular Chemistry, 2012, 10, 162. doi:10.1039/C1OB06534C. UCL RPS link pdf.
25. T. D. Sheppard, Strategies for the Synthesis of 2,3-Dihydrobenzofurans, Journal of Chemical Research, 2011, 377. doi:10.3184/174751911X13096980701749. UCL RPS link
24. T. D. Sheppard, Alternative Approaches to Enolate Chemistry, Synlett, 2011, 1340. doi:10.1055/s-0030-1260570. UCL RPS link
23. S. E. Mann, A. E. Aliev, G. J. Tizzard, T. D. Sheppard, Sulfur-Directed Olefin Oxidations: Observation of Divergent Reaction Mechanisms in the Palladium-Mediated Acetoxylation of Unsaturated Thioacetals, Organometallics, 2011, 30, 1772. doi:10.1021/om2000585. UCL RPS link
22. M. N. Pennell, M. G. Unthank, P. Turner, T. D. Sheppard, A General procedure for the synthesis of enones via gold-catalyzed Meyer-Schuster rerrangement of propargylic alcohols at room temperature, The Journal of Organic Chemistry, 2011, 76, 1479. doi:10.1021/jo102263t. UCL RPS link
Highlighted on www.organic-chemistry.org.
21. P. Starkov, T. D. Sheppard, Borate esters as convenient reagents for direct amidation of carboxylic acids and transamidation of primary amides, Organic and Biomolecular Chemistry, 2011, 9, 1320. doi:10.1039/C0OB1069C. UCL RPS link
20. C. Körner, Eun-Ang Raiber, Samuel E. M. Keegan, Daniel C. Nicolau, T. D. Sheppard, Alethea B. Tabor, An expedient synthesis of orthogonally protected lysinoalanine from Aloc-protected Garner's aldehyde, Tetrahedron Letters, 2010, 51, 6381. doi:10.1016/j.tetlet.2010.09.119. UCL RPS link
19. C. Körner, P. Starkov, T. D. Sheppard, An Alternative approach to aldol reactions: Gold-catalyzed formation of boron enolates from alkynes, Journal of the American Chemical Society, 2010, 132, 5968. doi:10.1021/ja102129c. UCL RPS link
18. T. D. Sheppard, Metal-catalysed Halogen Exchange Reactions of Aryl Halides, Organic and Biomolecular Chemistry 2009, 7, 1043. doi:10.1039/b818155a. UCL RPS link pdf
17. S. Ishikawa, T. D. Sheppard, J. M. D'Oyley, A. Kamimura, W. B. Motherwell, A Rapid Route to Aminocyclopropanes via Carbamatoorganozinc Carbenoids, Angewandte Chemie International Edition 2013, 52, 10060. doi: 10.1002/anie.201304720. UCL RPS link Open Access
16. R. W. Waller, L. J. Diorazio, B. A. Taylor, W. B. Motherwell, T. D. Sheppard, Isocyanide Based Multicomponent Reactions of Oxazolidines and Related Systems, Tetrahedron, 2010, 66, 6496. doi:10.1016/j.tet.2010.05.083. UCL RPS link
15. L. Jerome, T. D. Sheppard, A. E. Aliev, W. B. Motherwell, Intramolecular amidocyclopropanation reactions using diethoxymethyl-functionalised lactams as organozinc carbenoid precursors, Tetrahedron Letters, 2009, 50, 3709. doi:10.1016/j.tetlet.2009.03.224. UCL RPS link
14. W. B. Motherwell, G Bégis, D. Cladingboel, L. Jerome and T. D. Sheppard, Asymmetric Synthesis of Aminocyclopropanes and N-cyclopropylamino alcohols via Direct Amidocyclopropanation of Alkenes Using Chiral Organozinc Carbenoids, European Journal of Organic Chemistry, 2009, 1532. doi:10.1002/ejoc.200801033.
13. P. J. Gray, W. B. Motherwell, T. D. Sheppard and A. J. Whitehead, Observations on the Synthesis & Carbocyclisation Reactions of 6-oxohexa-2,3-dienoates, Synlett, special issue commemorating the 70th birthday of Professor Sir Jack Baldwin, 2008, 2097. doi:10.1055/s-2008-1078028.
12. S. S. Ramos, W. B. Motherwell, P. Almeida, L. Santos, T. D. Sheppard and M. C. Costa, Functionalisation of terpenoids at C-4 using organopalladium dimers - unusual participation of an adjacent alkene during the oxidation of the palladium-carbon bond, leading to cyclopropane formation, Tetrahedron 2007, 63, 12608. doi:10.1016/j.tet.2007.10.016. UCL RPS link
11. W. B. Motherwell, G Bégis, D. Cladingboel, L. Jerome and T. D. Sheppard, Observations on the direct amidocyclopropanation of alkenes using organozinc carbenoids, Tetrahedron 2007, 63, 6462. doi:10.1016/j.tet.2007.03.027. UCL RPS link
10. L. J. Diorazio, W. B. Motherwell, T. D. Sheppard and R. W. Waller, Observations on the reaction of N-alkyloxazolidines, isocyanides and carboxylic acids: A novel three-component reaction leading to N-acyloxyethylamino acid amides, Synlett 2006, 2281. doi:10.1055/s-2006-950413.
9. G Bégis, T. D. Sheppard, D. Cladingboel, W. B. Motherwell, and D. A. Tocher, Synthesis of enantiopure aminocyclopropanes by diastereoselective addition of a chiral amino substituted organozinc carbenoid to alkenes, Synthesis, special issue commemorating the 60th birthday of Professor SV Ley, 2005, 3186. doi:10.1055/s-2005-918469.
8. S. V. Ley, T. D. Sheppard, R. M. Myers and M. K. Chorgade, Chiral glycolate equivalents for the asymmetric synthesis of α-hydroxycarbonyl compounds, Bulletin of the Chemical Society of Japan 2007, 80, 1451. doi:10.1246/bcsj.80.1451.
7. S. V. Ley, D. J. Dixon, R. T. Guy, F. Rodriguez and T. D. Sheppard, Michael, Michael-aldol and Michael-Michael reactions of enolate equivalents of butane-2,3-diacetal protected glycolic acid derivatives, Organic and Biomolecular Chemistry, 2005, 3, 4095. doi:10.1039/b512410g.
6. D. J. Dixon, S. V. Ley, S. Lohmann and T. D. Sheppard, Synthesis of a ceramide sphingolipid as a potential sex pheromone of the hair crab erimacrus isenbeckii using butane-2,3-diacetal desymmetrised glycolic acid building blocks, Synlett 2005, 481. doi:10.1055/s-2005-862361.
5. S. V. Ley, D. J. Dixon, R. T. Guy, M. A. Palomero, A. Polara, F. Rodriguez and T. D. Sheppard, Studies on the generation of enolate anions from butane-2,3-diacetal protected glycolic acid derivatives and subsequent highly diastereoselective coupling reactions with aldehydes and acid chlorides, Organic and Biomolecular Chemistry 2004, 2, 3618. doi:10.1039/b412790k.
4. S. V. Ley, E. Diez, D. J. Dixon, R. T. Guy, P. Michel, G. L. Nattrass and T. D. Sheppard, Preparation of enantiopure butane-2,3-diacetals of glycolic acid and alkylation reactions leading to α-hydroxyacid and amide derivatives, Organic and Biomolecular Chemistry 2004, 2, 3608. doi:10.1039/b412788a.
3. D. J. Dixon, S. V. Ley, A. Polara and T. D. Sheppard, Highly diastereoselective lithium enolate aldol reactions of butane-2,3-diacetal desymmetrised glycolic acid and deprotection to enantiopure anti-2,3-dihydroxy esters, Organic Letters 2001, 3, 3749. doi:10.1021/ol016707n.
2. M. Ladlow, C. H. Legge, T. Neudeck, A. Pipe, T. D. Sheppard and L. L. Yang, Wavelength dependent photo-controlled differential release of compounds from solid phase resin, Chemical Communications 2003, 2048. doi:10.1039/b304477g.
1. M. S. Congreve, M. Ladlow, P. Marshall, N. Parr, J. J. Scicinski, T. D. Sheppard, E. Vickerstaffe and R. A. E. Carr, Reporter resins for solid-phase chemistry, Organic Letters 2001, 3, 507. doi:10.1021/ol006751n.
